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The outcomes illustrated that the RGD motif Improved GHK adsorption and accumulation in the skin, which contributed towards the regional peptide density and the bioactivities of GHK. Right here, Whilst sOtx2-GHK exhibited improved cell adhesion, its skin adsorption is weaker than RGD-GHK. One basis for the contradictory results of RGD-GHK binding i